Ultrapure Pharmaceutical Water for Injection (WFI) Separate Bed Deionizer (DI) Calculator & Guide

How do you size for hot sanitizable pharmaceutical twin bed demineralizer?

TDS (ppm mg/L CaCO3):
Estimated Conductivity (μS):
Flow Rate (GPD)*:
Flow Rate (GPM):
Hours in between regenerations:
Capacity (KGR):

Ultrapure Pharmaceutical Water for Injection (WFI) Separate Bed Deionizer (DI) Guide

The calculations above can be used as a guide for ultrapure, hot sanitizable pharmaceutical twin bed demineralizer (DI) sizing. Stainless steel systems (316L, 316, 304) are the best options for applications that need to be sanitized with a heat process. Systems are also available in FRP and lined carbon steel. Ultrapure DI systems are ideal for any application with need for TDS (conductivity) reduction where the water isn’t ideal (e.g. low TDS or small particle TSS) for reverse osmosis systems. They are also ideal for oil and gas, petrochemical and chemical, power generation, food and beverage and critical boiler water pre-treatment and many other ultrapure water (UPW) applications. Other calculators for specialized twin bed deionizer (DI) systems are here:

When sizing pharmaceutical deionizer systems, many variables exist that are beyond the scope of the pharma water for injection (WFI) twin bed demineralizer calculator & guide below. Water chemistry, pressure and temperature are all variables that have effects on water DI sizing and are not considered. These guides are to be used for quick estimates for sizing, general design and footprints of ultrapure water two bed deionizer systems for Pharmaceutical applications.

Detailed pharmaceutical water for injection (WFI) deionizer sizing, including configurations (e.g. single, twin, triple or special multiple tank configurations), control types (Allen Bradley, GE, Siemens PLC, progressive flow, additive flow) or specific specifications like 316L, 304, or 316 stainless steel, Hastelloy or specific instrument and valve types, it is important that you call or email Industrial Water Solutions at 800-820-9021. Industrial Water Solutions sales engineers are degreed mechanical engineers, experts in water processes and water treatment for pharmaceutical ultra-high purity DI systems as well as reverse osmosis, softeners, carbon filters, DI exchange tanks, pumps, ultra-pure water storage tanks, electrodeionization (EDI), ultraviolet (UV) systems, bacterial sub-micron filters, oxygen removal and carbon dioxide removal systems. Call us now to find the perfect system for all of your most critical two bed demineralizer pharmaceutical water needs.

Industrial Water Solutions also offers preventative maintenance, engineering consultation, equipment leasing, financing, and build, own, operate options. Let us know if you would like information on how these services can help you reduce downtime and capital risks.

Industrial Water Calculators

These industrial water calculators calculate total hardness, salt savings, boiler savings, and the appropriate size of industrial water softeners, industrial deionizers, and industrial reverse osmosis systems.

Legionella Control Softener Sizing Calculators & Guides

Industrial Reverse Osmosis Sizing Calculators & Guides

Ultrapure Water System Sizing Calculators & Guides

Industrial Steel Water Filter Sizing Calculators & Guides

Industrial Water Softener Sizing Calculators & Guides

Boiler Water Softener Sizing Calculators & Guides